Eric Reiter, INSIGHT Coordinator
 
Eric Reiter, PhD, HDR
Group leader of the MAG team
Coordinator of the INSIGHT project
 
UMR 6175 INRA-CNRS-Université de Tours-Haras Nationaux.
37380 Nouzilly, France.
Phone: +33 2 47 42 77 83
Fax: +33 2 47 42 77 43
 
Biography :

•	PhD in biological sciences, Université de Liège, Belgium, 1996 (Supervisors Dr J. Closset, Prof. G. Hennen).
•	HDR Université de Tours, France 2002 
•	Researcher at UMR6175 Physiologie de la Reproduction, Nouzilly, France since 1996 
•	Visiting scientist at the Laboratory of Receptor Biology (Prof. RJ Lefkowitz), Howard Hughes Medical Institute, Duke University, Durham, NC, USA (2003-2005) 
Responsabilités administratives : 
•	Head of the MAG team "Mécanismes d'action des gonadotropines" since 2006.

Research interests :

1990 – 1996 : Prostatic pathologies, molecular endocrinology, pituitary hormones.
1996 – present : cellular signalling, receptor biology, reproduction.
2003 – present : G protein-coupled receptors, pharmacology, drug design, systems biology.


I am currently studying the system biology of intracellular signalling networks triggered by plasma membrane receptors and how they generate an appropriate biological outcome (ie: proliferation, differentiation, apoptosis) in different physiological and pathological situations. I use the follicle stimulating hormone (FSH)-induced response in male and female gonadal cells as a model system. For that purpose, I am combining high throughput measurement of phosphorylation cascades to mathematical modelling.


Representative publications :

•	Troispoux C, Guillou F, Elalouf JM, Firsov D, Iacovelli L, De Blasi A, Combarnous Y, Reiter E, 1999. Involvement of G protein-coupled receptor kinases and arrestins in desensitization to follicle-stimulating hormone action. Molecular Endocrinology 13, 1599-1614. 
•	Crépieux P, Marion S, Martinat N, Fafeur V, Le Vern Y, Kerboeuf D, Guillou F, Reiter E, 2001. The ERK-dependent signalling is stage-specifically modulated by FSH during primary Sertoli cell maturation. Oncogene 20, 4696-4709. 
•	Reiter E, Marion S, Robert F, Troispoux C, Boulay F, Guillou F, Crépieux P, 2001. Kinase-inactive GRKs are able to attenuate follicle stimulating hormone-induced signaling. Biochemical and Biophysical Research Communications 282, 71-78.
•	Marion S, Robert F, Crepieux P, Martinat N, Troispoux C, Guillou F, Reiter E, 2002. G protein-coupled receptor kinases and beta arrestins are relocalized and attenuate cyclic 3',5'-adenosine monophosphate response to follicle-stimulating hormone in rat primary Sertoli cells. Biology of Reproduction 66, 70-76.
•	Barnes W.G., Reiter E., Violin J.D., Ren X.R., Milligan G., Lefkowitz R.J. 2005. Beta-arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation The Journal of Biological Chemistry 280 (9), 8041-8050.
•	Hunton D.L., Barnes W.G., Kim J., Ren X.R., Violin J.D., Reiter E., Milligan G., Dhavalkumar D., Patel D., Lefkowitz R.J. 2005. beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis Molecular Pharmacology 67, 1229-1236.
•	Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E, Wei H, Lefkowitz RJ, 2005. Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. Proceedings of the National Academy of Sciences of the USA 102 (5), 1442-1447. 
•	Ren XR, Reiter E, Ahn S, Kim J, Chen W, Lefkowitz RJ, 2005. Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. Proceedings of the National Academy of Sciences of the USA 102 (5), 1448-1453.
•	Lecureuil C, Tesseraud S, Kara E, Martinat N, Sow A, Fontaine I, Gauthier C, Reiter E, Guillou F, Crepieux P, 2005. Follicle-Stimulating Hormone activates p70 ribosomal protein S6 kinase by protein kinase A-mediated dephosphorylation of Thr 421/ Ser 424 in primary Sertoli cells. Molecular Endocrinology 19 (7) , 1812-1820. 
•	Shenoy SK., Drake MT., Nelson CD., Houtz DA., Xiao K., Madabushi S., Reiter E., Premont RT., Lichtarge O., Lefkowitz RJ. 2006 beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem. 281(2):1261-73.
•	Gesty-Palmer D., Chen M., Reiter E., Ahn S., Nelson CD., Loomis CR., Spurney RF., Luttrell LM., Lefkowitz RJ. 2006 Distinct beta-arrestin and G protein dependent pathways for parathyroid hormone receptor stimulated ERK1/2 activation. J Biol Chem. 281(16):10856-64.
•	Reiter E, Lefkowitz RJ, 2006. GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends in Endocrinology and Metabolism 17, 159-165. 
•	Marion S, Kara E, Crépieux P, Piketty V, Martinat N, Guillou F, Reiter E, 2006. G protein-coupled receptor kinase 2 and b -arrestins are re-localized to follicle-stimulating hormone receptor-enriched compartments upon agonist stimulation in rat primary Sertoli cells. Journal of Endocrinology 190, 341-350.
•	Kara E, Crépieux P, Gauthier C, Martinat N, Piketty V, Guillou F, Reiter E, 2006. Identification of a phosphorylation cluster in the C-terminus of the follicle-stimulating hormone receptor (FSH-R) which is important for desensitization and internalization but not beta-arrestin-mediated Erk activation. Molecular Endocrinology 20:3014-26.
•	Barthet G., Framery B., Gaven F., Pellissier L., Reiter E., Claeysen S., Bockaert J., Dumuis A. 2007. 5-HT4 receptors activate ERKs through a pathway independent of G-protein and β-arrestin signalling. Molecular Biology of the Cell, 18(6):1979-91.